An ISO9001 Certified Supplier of Pharmaceutical Ingredients and Specialty Chemicals

SJF 1528

Inquiry

Cat Number

API2230821380

CAS Number

2230821-38-0

For research use only. We do not supply to patients.

For pharmaceutical-grade products or other inquiries, please contact our experts.

Product Detail

CAS Number

2230821-38-0

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Description

Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. Comprises the EGFR inhibitor lapatinib (Cat. No. 6811) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells).

Molecular Formula

C55H57ClFN7O8S

Molecular Weight

1030.61

You Might Also Like