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SJF 1528

SJF 1528

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Cat Number
API2230821380
CAS Number
2230821-38-0

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CAS Number
2230821-38-0
Storage
Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.
Description
Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. Comprises the EGFR inhibitor lapatinib (Cat. No. 6811) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells).
Molecular Formula
C55H57ClFN7O8S
Molecular Weight
1030.61
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Sunday : 9.30 AM–1.00 PM
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