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Cat Number: API923288953

Nilotinib hydrochloride

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CAS Number

923288-95-3

Synonyms

AMN-107 HCl

Description

Nilotinib hydrochloride(AMN-107 HCl) is an orally available Bcr-Abl tyrosine kinase inhibitor with antitumor activity for modulation of neuroinflammation and cognitive deficits, and may be used in studies of chronic myelogenous leukemia.

Molecular Formula

C28H23ClF3N7O

Molecular Weight

565.98

Smiles

Cl.O=C(NC=1C=C(C=C(C1)C(F)(F)F)N2C=NC(=C2)C)C3=CC=C(C(=C3)NC=4N=CC=C(N4)C5=CN=CC=C5)C

Purity

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 90 mg/ml (159.02 mM)Ethanol: 1 mg/ml (1.77 mM)

Standard

CP/EP/USP/In-house; Facility GMP

Qualification

DMF/CEP/EMA

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