Sincalide

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Cat Number

API0231578

CAS Number

25126-32-3

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Product Detail Description Customer Q&A

CAS Number

25126-32-3

EINECS

246-639-0

Storage

Store at 2-8℃

Synonyms

CCK-8; Kinevac; Sincalida; Sincalidum; Syncalide; SQ 19844; cholecystokinin C-terminal octapeptide

Molecular Formula

C49H62N10O16S3

Molecular Weight

1143.3

Smiles

CSCC[C@@H](C(=O)NCC(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N)NC(=O)[C@H](CC4=CC=C(C=C4)OS(=O)(=O)O)NC(=O)[C@H](CC(=O)O)N

Appearance

White to off-white powder

Melting Point

>193℃ (dec.)

Relative Density

1.440±0.06

General Description

Sincalide is a synthetic octapeptide identical to the C-terminal segment of the endogenous hormone cholecystokinin (CCK). It is administered intravenously as a diagnostic agent to stimulate gallbladder contraction and pancreatic enzyme secretion. The compound has a rapid onset and short duration of action, making it suitable for use during gastrointestinal imaging procedures.

Mechanism of Action

Upon intravenous injection, sincalide binds selectively to CCK-1 receptors located on gallbladder smooth muscle and pancreatic acinar cells. This interaction triggers smooth muscle contraction in the gallbladder wall, leading to bile ejection into the duodenum. Simultaneously, it stimulates pancreatic acinar cells to release digestive enzymes, facilitating functional assessment of pancreatic exocrine reserve.

Application

Sincalide is indicated as a diagnostic adjunct for evaluating gallbladder emptying using hepatobiliary scintigraphy (HIDA scan) to assess for chronic acalculous cholecystitis or biliary dyskinesia. It is also used to stimulate pancreatic secretion during pancreatic function testing. The drug may cause transient abdominal pain or nausea during administration, which typically resolves quickly after the infusion ends.

Does Sincalide require strict cold chain storage as a synthetic peptide?

Yes, it must be stored at 2-8°C (refrigerated). As a peptide, it is thermally labile and rapidly degrades at room temperature via deamidation and oxidation.

Is Sincalide sensitive to light during handling and storage?

Yes, it is photosensitive. Store in light-resistant containers and handle under subdued light to prevent photodegradation of the tyrosine and methionine residues.

What is the stability of Sincalide after reconstitution for diagnostic use?

Reconstituted solutions have very limited stability (typically 8-24 hours under refrigeration). We provide detailed in-use stability data for various diluents.

How is the purity of Sincalide confirmed given its peptide nature?

We use a combination of reverse-phase HPLC for chemical purity, SEC-HPLC for aggregates, and mass spectrometry for identity confirmation on each batch.