Saralasin Acetate

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Cat Number

API39698787

CAS Number

39698-78-7

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Product Detail Description Customer Q&A

CAS Number

39698-78-7

Synonyms

Saralasin acetate hydrate

Molecular Formula

C44H71N13O13

Molecular Weight

990.1

Smiles

C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC.CC(=O)O.O

Melting Point

256℃

General Description

Saralasin Acetate is a synthetic octapeptide analog of angiotensin II, classified as a competitive angiotensin II receptor antagonist. It was among the earliest pharmacological tools for investigating the renin-angiotensin system.

Mechanism of Action

Saralasin competitively occupies angiotensin II type 1 receptors, blocking endogenous angiotensin II-mediated vasoconstriction and aldosterone secretion. Its partial agonist activity can transiently elevate blood pressure before antagonistic effects predominate.

Application

Used in the diagnostic evaluation of renin-mediated hypertension. Saralasin Acetate is indicated for identifying surgically correctable renovascular hypertension and assessing renin-angiotensin system contribution.

What is the diagnostic value of Saralasin Acetate in hypertension evaluation?

Saralasin provides a pharmacological method to identify renin-dependent hypertension by demonstrating blood pressure reduction following angiotensin II receptor blockade.