Description
Rucaparib (AG014699) camsylate is an orally active inhibitor of PARP proteins (PARP-1, PARP-2, and PARP-3) with a Ki=1.4 nM for PARP-1, and also inhibits hexose hexaphosphate dehydrogenase (H6PD). Rucaparib camsylate has potential for investigation in debulking resistant prostate cancer (CRPC) studies.