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(R)-Afatinib

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Cat Number

API439081171

CAS Number

439081-17-1

For research use only. We do not supply to patients.

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Product Detail

CAS Number

439081-17-1

Description

(R)-Afatinib ((R)-BIBW 2992), an isomer of Afatinib, is a potent, orally administered, irreversible inhibitor targeting the ErbB family (EGFR and HER2) with IC50 values of 0.5 nM for EGFR wt, 0.4 nM for EGFR L858R, 10 nM for EGFR L858R/T790M, and 14 nM for HER2, holding potential for research into esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC), and gastric cancer.

Molecular Formula

C24H25ClFN5O3

Molecular Weight

485.94

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