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Cat Number: API321344325

R-130823

CAS Number

321344-32-5

Description

R-130823 is a ighly selective inhibition against mitogen-activated protein kinase p38alpha (IC50=22 nM). The release of tumor necrosis factor-alpha, interleukin-1beta, -6 and -8 was inhibited in lipopolysaccharide-stimulated human blood pretreated by R-130823 , with IC50 values of 0.089, 0.066, 0.95 and 0.16 microM, respectively.

Molecular Formula

C28H26FN3

Molecular Weight

423.52

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