Haloprogin

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Cat Number

API0232226

CAS Number

777-11-7

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Product Detail Description Customer Q&A

CAS Number

777-11-7

EINECS

212-286-6

Storage

Store at room temperature

Synonyms

Halotex; Mycanden; Mycilan; Polik; Haloprogine; Haloprogina

Molecular Formula

C9H4Cl3IO

Molecular Weight

361.4

Smiles

C1=C(C(=CC(=C1Cl)Cl)Cl)OCC#CI

Appearance

White to off-white or pale yellow crystals

Melting Point

113-114°C

Boiling Point

477.49°C (Estimate)

Relative Density

1.9350 (Estimated)

General Description

Haloprogin is a synthetic halogenated diphenyl ether antifungal agent, with a chlorine and an iodine substituent on its diphenyl ether ring. Its chemical structure is 1,2,4-trichloro-3-(4-iodophenyl)benzene. Haloprogin is a white to off-white crystalline powder, practically insoluble in water but soluble in organic solvents.

Mechanism of Action

Haloprogin exerts its antifungal activity by inhibiting the synthesis of ergosterol, a critical component of the fungal cell membrane, and by disrupting the cellular membrane integrity. It also interferes with the fungal cytochrome P450 enzymes, leading to the accumulation of toxic sterols and cell death. The drug is fungicidal against dermatophytes and yeasts.

Application

Haloprogin is indicated for the topical treatment of tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm) caused by Trichophyton, Microsporum, and Epidermophyton species. It is also effective against cutaneous candidiasis.

Does Haloprogin require protection from light during long-term storage?

Yes, it is photosensitive. UV exposure can cause photodegradation and discoloration of the halogenated phenyl ring. Store in light-resistant containers, preferably amber glass.