General Description
Potassium Phosphate Dibasic (also known as dipotassium hydrogen phosphate or K2HPO4) is an inorganic phosphate salt providing both potassium and phosphate ions in a physiologically balanced ratio. As a pharmaceutical-grade reagent and active ingredient, it is used in nutritional formulations, parenteral fluids, and as a buffering agent in pharmaceutical preparations requiring phosphate-based buffer systems.
Mechanism of Action
Potassium Phosphate Dibasic dissociates into potassium (K+) and dibasic phosphate (HPO4 2-) ions. Phosphate is a critical component of ATP, nucleic acids, cell membrane phospholipids, and the 2,3-bisphosphoglycerate (2,3-BPG) pathway in red blood cells. The phosphate buffer system (H2PO4-/HPO4 2-) contributes to the maintenance of systemic acid-base balance, and adequate intracellular phosphate is required for optimal energy metabolism and cellular function.
Application
Potassium Phosphate Dibasic is used as a potassium and phosphate supplement in the treatment and prevention of hypokalemia and hypophosphatemia, particularly in patients receiving parenteral nutrition or those with renal tubular acidosis. It is also a component of buffered pharmaceutical formulations and is used in hemodialysis fluids.