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Cat Number: API1114544318

Ponatinib Hydrochloride

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CAS Number

1114544-31-8

Synonyms

AP24534 Hydrochloride, AP 24534, AP-24534 Hydrochloride, Ponatinib hydrochloride

Description

Ponatinib Hydrochloride (AP-24534 Hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

Molecular Formula

C29H28ClF3N6O

Molecular Weight

569.02

Smiles

Cl.CN1CCN(CC2CCC(NC(=O)C3CCC(C)C(C3)C#CC3CNC4CCCNN34)CC2C(F)(F)F)CC1

Purity

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 60 mg/mL (105.44 mM), Sonication is recommended.

Standard