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Pexidartinib hydrochloride

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Cat Number

API2040295030

CAS Number

2040295-03-0

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Product Detail

CAS Number

2040295-03-0

Description

Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, selective, orally active, ATP-competitive inhibitor of colony-stimulating factor 1 (CSF1R or M-CSFR) (IC50: 20 nM) and c-Kit (IC50: 10 nM), with 10-100 times greater selectivity for these targets compared to FLT3 (IC50: 160 nM), KDR (VEGFR2) (IC50: 350 nM), and LCK (IC50: 860 nM). Pexidartinib hydrochloride induces apoptosis and exhibits anti-tumor effects.

Molecular Formula

C20H16Cl2F3N5

Molecular Weight

454.28

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