Norgestrel

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Cat Number

API0232269

CAS Number

797-63-7

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Product Detail Description Customer Q&A

CAS Number

797-63-7

EINECS

229-433-5

Storage

Store at 2-8°C

Synonyms

D-Norgestrel; Mirena; Levonova; Microval; NORPLANT; (-)-Norgestrel

Molecular Formula

C21H28O2

Molecular Weight

312.4

Smiles

CC[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC(=O)CC[C@H]34

Appearance

White solid

Melting Point

239-241°C (lit.)

Boiling Point

392.36°C (Estimate)

Relative Density

1.0697 (Estimate)

General Description

Norgestrel is a synthetic progestin with a 13β-ethyl group and a 17α-ethinyl group, structurally related to norethisterone. Its chemical structure is 13β-ethyl-17α-ethinyl-17β-hydroxy-4-gonen-3-one. Norgestrel is a white to off-white crystalline powder, practically insoluble in water but soluble in organic solvents. It is a potent progestational agent.

Mechanism of Action

Norgestrel acts as a progestin by binding to the progesterone receptor, suppressing ovulation by inhibiting the release of gonadotropins from the pituitary gland. It also changes the cervical mucus and endometrium, making it less favorable for implantation. The drug has weak androgenic and anti-estrogenic activity.

Application

Norgestrel is indicated as a component of combined oral contraceptives and as a single-agent contraceptive. It is also used for the treatment of menstrual disorders, such as endometriosis and dysmenorrhea. The drug is effective in preventing pregnancy and regulating the menstrual cycle.