Pergolide Mesylate

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Cat Number

API0232220

CAS Number

66104-23-2

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Product Detail Description Customer Q&A

CAS Number

66104-23-2

EINECS

636-270-7

Storage

Store at 2-8°C

Synonyms

Pergolide Methanesulfonate; Pergolide mesilate; DTXSID6040583; LY127809; NSC-319773; NSC-758442; LY-127809

Molecular Formula

C20H30N2O3S2

Molecular Weight

410.6

Smiles

CCCN1C[C@@H](C[C@H]2[C@H]1CC3=CNC4=CC=CC2=C34)CSC.CS(=O)(=O)O

Appearance

White to off-white solid

Melting Point

252-254°C

Boiling Point

491.3°C at 760 mmHg

Relative Density

1.1±0.1

General Description

Pergolide mesylate is a synthetic ergoline derivative with a methylthio group, structurally related to the ergot alkaloids. Its chemical structure is (8β)-8-[(methylthio)methyl]-6-propylergoline mesylate. Pergolide is a white to off-white powder with a molecular weight of 410.6 Da (as the mesylate). It is a long-acting dopamine receptor agonist with high affinity for D1, D2, and D3 receptors.

Mechanism of Action

Pergolide acts as a potent agonist at dopamine receptors, particularly D2 and D3, in the nigrostriatal pathway, compensating for the dopaminergic deficit in Parkinson's disease. It also has weak activity at serotonin and alpha-adrenergic receptors. The drug's prolonged action allows for once-daily dosing. Pergolide also inhibits prolactin secretion by acting on D2 receptors in the pituitary.

Application

Pergolide was indicated as an adjunct to levodopa in the treatment of Parkinson's disease and for the management of hyperprolactinemia.

Does Pergolide Mesylate require refrigerated storage as an ergoline derivative?

Yes, it should be stored at 2-8°C. At room temperature, oxidation and degradation of the indole ring occur rapidly, reducing potency.

Is Pergolide Mesylate sensitive to light and oxygen during handling?

Yes, it is highly sensitive to light and oxygen. Store in light-resistant, airtight containers under inert gas (nitrogen). Handle under subdued light.