Pancuronium Bromide

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Cat Number

API15500660

CAS Number

15500-66-0

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Product Detail Description Scientific Support Customer Q&A

CAS Number

15500-66-0

EINECS

239-532-5

Storage

2-8℃

Synonyms

1,1'-(3alpha,17beta-dihydroxy-5alpha-androstan-2beta,16beta-ylene)bis[1-methyl

Molecular Formula

C35H60Br2N2O4

Molecular Weight

732.7

Smiles

CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2(C[C@@H]1[N+]4(CCCCC4)C)C)CC[C@]5([C@H]3C[C@@H]([C@@H]5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-].[Br-]

Appearance

Off-white solid

Melting Point

215℃

General Description

Pancuronium Bromide is a bisquaternary aminosteroid non-depolarizing neuromuscular blocking agent with a long duration of action and mild vagolytic effects that may produce tachycardia.

Mechanism of Action

Pancuronium competitively occupies nicotinic acetylcholine receptors at the neuromuscular junction without activation, preventing acetylcholine-mediated endplate depolarization. Its vagolytic effect results from muscarinic receptor blockade.

Application

Used as an adjunct in surgical anesthesia. Pancuronium Bromide is indicated for prolonged muscle relaxation during extended surgical procedures and for facilitating mechanical ventilation.

The in vitro effect of pancuronium bromide on lymphocyte apoptosis was investigated at a clinically relevant concentration of 0.136 micromol/l for 3 hours. Treatment with pancuronium resulted in a tenfold increase in the frequency of apoptotic lymphocytes compared to control cultures. Pancuronium significantly upregulated the expression of Fas with a sixfold increase, Fas ligand with a fourfold increase, and ICEp20 with a fivefold increase.
Pancuronium exposure also led to a sevenfold increase in the percentage of cells exhibiting dissipation of mitochondrial membrane potential and a sevenfold increase in the generation of mitochondrial reactive oxygen species. These changes were associated with a decrease in glutathione levels. The findings suggest that pancuronium induces lymphocyte apoptosis through both death receptor and mitochondrial pathways, which may contribute to the transient immune suppression observed in the post-surgical period.

Fig. 1 Effect of pancuronium on Fas, FasL and ICEp20 expression of CD4 cells. (Delogu G.; et al. 2003)

References

Delogu G, et al. Pancuronium bromide, a non‐depolarizing muscle relaxant which promotes apoptosis of blood lymphocytes in vitro. Acta anaesthesiologica scandinavica, 2003, 47(9): 1138-1144.

What cardiovascular effect distinguishes Pancuronium from other neuromuscular blockers?

Pancuronium produces mild vagolytic effects causing moderate tachycardia, which may be beneficial in patients requiring maintained heart rate during anesthesia.