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Olaparib

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Cat Number

API763113220

CAS Number

763113-22-0

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Product Detail

CAS Number

763113-22-0

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Synonyms

AZD2281, KU0059436

Description

Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 μM), and is selective and orally active. Olaparib exhibits autophagy and mitochondrial autophagy activation activity.

Molecular Formula

C24H23FN4O3

Molecular Weight

434.46

Smiles

C(C=1C=2C(C(=O)NN1)=CC=CC2)C3=CC(C(=O)N4CCN(C(=O)C5CC5)CC4)=C(F)C=C3

Relative Density

1.43

Standard

USP/In-house; Facility GMP

Qualification

USDMF/ASMF