NSE

2-phospho-D-glycerate hydrolyase, ENO2, Enolase 2, gamma-Enolase, Neural enolase, neurone-specific enolase, Neuron-specific enolase, NSE

Neuron specific enolase (NSE), also known as ENO2 or gamma-enolase, is a dimeric, Mg2+-dependent enzyme that catalyzes the dehydration of 2-phospho-D glycate (PGA) to phosphoenolpyruvate (PEP) in the glycolytic pathway and catalyzes the reverse reaction in gluconeogenesis. NSE is a 47.1 kDa member of the Enolase family of enzymes. It is expressed in developing neurons and glia, is known to catalyze the generation of phosphoenolpyruvate, and is suggested to possess neurotrophic activity for neurons, likely through an extracellular mechanism. Human Neuron-specific Enolase is 433 amino acids (aa) in length. The enzymatic site spans most of the length of the molecule. Neuron-specific Enolase exists as both a noncovalently-linked homodimer, or heterodimer with alpha-enolase. Full-length human Enolase 2 shares 99% aa identity with both murine and canine Enolase 2. It shares 83% aa identity with human enolases 1 and 3.

Approximately 47.1 kDa.

Sterile Filtered White lyophilized (freeze-dried) powder.

>96% by SDS-PAGE and HPLC analyses.