NRG1-α

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Cat Number

92707ES

For research use only. We do not supply to patients.

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Product Detail

Synonyms

ARIA; GGF2; HGL; HRG; HRG1; MST131

Description

The neuregulin family of structurally related glycoproteins comprises products from four distinct but related genes, Nrg-1, Nrg-2, Nrg-3, and Nrg-4. All NRG1 isoforms contain an EGF-like domain that is required for their direct binding to the ErbB3 or ErbB4 receptor tyrosine kinases. The ErbB3 or ErbB4 subsequently recruits and heterodimerizes with ErbB2, resulting in tyrosine phosphorylation and NRG1 signaling.

Molecular Weight

Approximately 7.4 kDa.

Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Purity

> 97 % by SDS-PAGE and HPLC analyses.

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