Moricizine Hydrochloride

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Cat Number

API0231627

CAS Number

29560-58-5

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Product Detail Description Customer Q&A

CAS Number

29560-58-5

Storage

Store at room temperature

Synonyms

Ethmozine; Moracizine hydrochloride; Moricizine HCl; Ethmozin; Etmozin

Molecular Formula

C22H26ClN3O4S

Molecular Weight

464

Smiles

CCOC(=O)NC1=CC2=C(C=C1)SC3=CC=CC=C3N2C(=O)CCN4CCOCC4.Cl

Appearance

White to yellowish-brown crystalline powder

Boiling Point

625℃ at 760 mmHg

General Description

Moricizine hydrochloride (also known as ethmozine) is a phenothiazine derivative with class I antiarrhythmic properties, classified as a class IB agent but with unique characteristics. It was available for the treatment of life-threatening ventricular arrhythmias.

Mechanism of Action

Moricizine slows the fast inward sodium channel current during phase 0 of the action potential, predominantly in Purkinje fibers and ventricular muscle. It also reduces automaticity and prolongs effective refractory period without significantly altering QT interval. Unlike other class I agents, moricizine has minimal effects on conduction velocity at therapeutic concentrations. The drug also possesses membrane-stabilizing and mild anti-ischemic properties.

Application

Prior to withdrawal, moricizine was indicated for the treatment of documented ventricular arrhythmias, including sustained ventricular tachycardia, that were life-threatening in nature. It was used after failure of more established antiarrhythmics. The Cardiac Arrhythmia Suppression Trial (CAST) demonstrated increased mortality in post-myocardial infarction patients, leading to its fall from use.

Does Moricizine Hydrochloride require protection from light during long-term storage?

Yes, it is photosensitive. UV light can cause photodegradation and discoloration. Store in light-resistant containers, preferably amber glass or original opaque packaging.

What is the recommended storage temperature for Moricizine Hydrochloride?

Store at controlled room temperature (15-25°C). Avoid temperatures above 30°C, which can accelerate hydrolysis of the carbamate group.

Is Moricizine Hydrochloride stable under high-humidity conditions?

It is moderately hygroscopic. Storage in tightly sealed containers with desiccant is recommended to prevent caking and potential degradation.

How is the impurity phenothiazine-2-carboxylic acid derivative monitored?

This process-related impurity is quantified using a stability-indicating HPLC method, ensuring it remains within ICH qualification thresholds.