Methoxamine Hydrochloride

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Cat Number

API0232080

CAS Number

61-16-5

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Product Detail Description Customer Q&A

CAS Number

61-16-5

EINECS

200-499-7

Storage

Store at room temperature

Synonyms

Vasoxyl hydrochloride; Vasylox hydrochloride; Pressomin hydrochloride; Methoxamine HCl

Molecular Formula

C11H18ClNO3

Molecular Weight

247.72

Smiles

C[C@@H]([C@@H](C1=C(C=CC(=C1)OC)OC)O)N.Cl

Appearance

White to off-white crystalline powder

Melting Point

212-216°C

Boiling Point

368.4±42.0°C (Predicted)

Relative Density

1.117±0.06

General Description

Methoxamine hydrochloride is a synthetic sympathomimetic amine, a selective alpha-1 adrenergic receptor agonist, with a dimethoxyphenyl and an amine group. Its chemical structure is 2-amino-1-(2,5-dimethoxyphenyl)-1-propanol hydrochloride. It is a white to off-white crystalline powder that is soluble in water.

Mechanism of Action

Methoxamine acts as a selective agonist at alpha-1 adrenergic receptors, causing vasoconstriction and an increase in peripheral vascular resistance. This leads to an increase in blood pressure. The drug has minimal beta-adrenergic effects, making it useful for the treatment of hypotension without causing tachycardia.

Application

Methoxamine is indicated for the treatment of hypotension during anesthesia and for the management of shock. It is also used for the treatment of paroxysmal supraventricular tachycardia.

Does Methoxamine Hydrochloride require protection from light and oxygen during storage?

Yes, it is sensitive to light and oxygen. The phenolic group is prone to oxidation and photodegradation. Store in airtight, light-resistant containers, preferably under inert gas.

What is the recommended storage temperature for Methoxamine Hydrochloride?

Store at controlled room temperature (15–25°C). Avoid excessive heat above 30°C, which accelerates oxidative degradation and discoloration.

Is Methoxamine Hydrochloride stable in injectable formulations?

Aqueous solutions require antioxidants (e.g., sodium metabisulfite) and protection from light.

How is the impurity methoxamine N-oxide (an oxidative degradation product) monitored?

This degradation product is quantified using a stability-indicating HPLC method with electrochemical detection, ensuring it remains within pharmacopoeial limits.