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IR-Crizotinib

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Cat Number

API2387927742

CAS Number

2387927-74-2

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Product Detail

CAS Number

2387927-74-2

Description

IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranial glioblastoma (GBM) localization in mice. It has the ability to cross the blood-brain barrier and fluorescently mark GBM, and demonstrates efficacy in inhibiting glioma proliferation and invasion both in vitro and in vivo, making it significant in cancer research.

Molecular Formula

C53H57Cl2FIN7O

Molecular Weight

1024.88

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