Iodixanol

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Cat Number

API92339112

CAS Number

92339-11-2

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Product Detail Description Scientific Support Customer Q&A

CAS Number

92339-11-2

EINECS

618-837-0

Storage

2-8℃

Synonyms

5-[acetyl-[3-[N-acetyl-3,5-bis[(2,3-dihydroxypropylamino)-oxomethyl]-2,4,6-triiodoanilino]-2-hydroxypropyl]amino]-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide

Molecular Formula

C35H44I6N6O15

Molecular Weight

1550.2

Smiles

CC(=O)N(CC(CN(C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I)C(=O)C)O)C2=C(C(=C(C(=C2I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I

Appearance

Liquid

Melting Point

262-267℃

Boiling Point

1251℃

Relative Density

1.3

General Description

Iodixanol is a non-ionic, dimeric, iodinated X-ray contrast medium belonging to the class of iso-osmolar contrast agents. Its dimeric structure incorporates six iodine atoms per molecule and achieves iso-osmolality with blood at all clinically relevant concentrations, minimizing osmotic stress on sensitive tissues.

Mechanism of Action

Iodixanol provides radiographic contrast through attenuation of X-rays by its iodine atoms. As a dimeric non-ionic compound with six iodine atoms per molecule, it achieves iso-osmolality with blood plasma, significantly reducing osmotic stress on endothelial cells, the blood-brain barrier, and renal tubular cells compared to low-osmolar contrast agents.

Application

Used in diagnostic imaging for computed tomography (CT), angiography, and cardiovascular imaging. Iodixanol is a non-ionic iso-osmolar contrast agent that minimizes osmotic stress on endothelial cells, the blood-brain barrier, and renal tubular cells, making it particularly suitable for patients with renal impairment or cardiac conditions.

A meta-analysis of 16 randomized controlled trials (2,763 subjects) compared the renal safety of the iso-osmolar contrast medium iodixanol with low-osmolar contrast media (LOCM). Overall, no significant difference in contrast-induced acute kidney injury (CI-AKI) was found between iodixanol and pooled LOCM (risk ratio: 0.79; 95% CI: 0.56–1.12). Rates of post-procedure hemodialysis and death were also similar. However, subgroup analyses showed that iodixanol was associated with less CI-AKI than iohexol and ioxaglate, but no difference was observed when compared with iopamidol, iopromide, ioversol, or iomeprol.

Fig. 1 Forest Plot of RR of CI-AKI of Patients Undergoing Coronary Angiography. (Reed M.; et al. 2009)

References

Reed M, et al. The relative renal safety of iodixanol compared with low-osmolar contrast media: a meta-analysis of randomized controlled trials. JACC: Cardiovascular Interventions, 2009, 2(7): 645-654.

What sets Iodixanol apart from other iodinated contrast media?

Iodixanol is iso-osmolar with human blood plasma at all concentrations due to its dimeric non-ionic structure, whereas low-osmolar agents such as iohexol have higher osmolality, reducing the risk of contrast-induced nephropathy.

What storage conditions are required?

Iodixanol should be stored at 2-8℃ in a tightly sealed container, protected from light.

What purity grade is available?

Iodixanol is supplied as a high-purity grade suitable for medical imaging R&D and pharmaceutical manufacturing.

Can packaging be customized?

Packaging specifications and order quantities can be customized to meet specific R&D and manufacturing requirements.