Iodipamide Sodium

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Cat Number

API0231637

CAS Number

2618-26-0

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Product Detail Description Customer Q&A

CAS Number

2618-26-0

EINECS

220-049-3

Storage

Store at room temperature

Synonyms

Cholografin sodium; Iodipamide disodium salt; UNII-3J6WZA9PXS; 3J6WZA9PXS; EINECS 220-049-3

Molecular Formula

C20H12I6N2Na2O6

Molecular Weight

1183.7

Smiles

C1=C(C(=C(C(=C1I)NC(=O)CCCCC(=O)NC2=C(C=C(C(=C2I)C(=O)[O-])I)I)I)C(=O)[O-])I.[Na+].[Na+]

Appearance

White powder

Relative Density

2.8 (Predicted)

General Description

Iodipamide sodium (also known as adipiodone) is an ionic, high‑osmolar, tri‑iodinated contrast agent specifically developed for intravenous cholangiography and cholecystography. It is administered intravenously, where it is taken up by hepatocytes and excreted into the bile, opacifying the biliary tract.

Mechanism of Action

Iodipamide contains six iodine atoms per molecule, providing high X‑ray attenuation. Following intravenous injection, the drug is rapidly bound to plasma albumin and transported to the liver. It is actively taken up by hepatocytes via organic anion transport proteins (OATPs) and secreted into the bile without significant metabolism. The resulting concentration in the bile duct and gallbladder allows radiographic visualization.

Application

Iodipamide was indicated for oral cholecystography (when given orally as the calcium salt) and intravenous cholangiography to detect gallstones, biliary obstruction, or bile duct abnormalities. Its use has been superseded by endoscopic retrograde cholangiopancreatography (ERCP), magnetic resonance cholangiopancreatography (MRCP), and non‑ionic CT contrast.

Does Iodipamide Sodium require protection from light during storage?

Yes, it is photosensitive. Light exposure can cause photodegradation and release of free iodine. Store in light-resistant, tightly sealed containers, preferably amber glass.

What is the recommended storage temperature for Iodipamide Sodium?

Store at controlled room temperature (15-25°C). Avoid excessive heat above 30°C, which accelerates decomposition and iodine liberation.

Is Iodipamide Sodium stable in solution for radiographic contrast use?

Formulated solutions are stable when stored at room temperature and protected from light. We provide stability data for various concentrations and pH ranges (optimal pH 6.5-7.5).

How is the free iodine content monitored during stability?

Free iodide is quantified using ion chromatography or a validated colorimetric method, ensuring it remains below pharmacopoeial limits for injectable contrast agents.