Indecainide Hydrochloride

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Cat Number

API0231632

CAS Number

73681-12-6

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Product Detail Description Customer Q&A

CAS Number

73681-12-6

Storage

Store at room temperature

Synonyms

Indecainide HCl; LY 135837; M76V0B96L5; 9H-Fluorene-9-carboxamide, 9-(3-((1-methylethyl)amino)propyl)-, monohydrochloride; LY-135837

Molecular Formula

C20H25ClN2O

Molecular Weight

344.9

Smiles

CC(C)NCCCC1(C2=CC=CC=C2C3=CC=CC=C31)C(=O)N.Cl

Boiling Point

509.3℃ at 760 mmHg

Relative Density

1.109 (Predicted)

General Description

Indecainide hydrochloride is a class Ic antiarrhythmic agent that was developed for the suppression of ventricular arrhythmias. It is a congener of flecainide, with similar sodium channel blocking properties. The drug was never widely marketed and is now of primarily historical interest due to the emergence of safer agents.

Mechanism of Action

Indecainide potently blocks the fast inward sodium channel in cardiac Purkinje fibers and ventricular muscle, significantly slowing phase 0 depolarization. This results in slowed conduction velocity throughout the His‑Purkinje system and ventricles, prolonging QRS duration. The drug has minimal effect on repolarization (QT interval). It also exhibits some local anesthetic and membrane‑stabilizing properties.

Application

Indecainide was investigated for the treatment of life‑threatening ventricular arrhythmias, including sustained ventricular tachycardia, in patients who did not respond to class I agents. No current clinical use exists, and the drug serves only as a research tool for understanding sodium channel pharmacology.

Does Indecainide Hydrochloride require protection from light during storage?

Yes, it is photosensitive. UV light can cause photodegradation and discoloration. Store in light-resistant containers, preferably amber glass.

What is the recommended storage temperature for Indecainide Hydrochloride?

Store at controlled room temperature (15-25°C). Avoid temperatures above 30°C, which can accelerate oxidative degradation of the indane ring.

Is Indecainide Hydrochloride hygroscopic, and how is this managed?

It is moderately hygroscopic. Storage in tightly sealed containers with desiccant is essential to prevent moisture absorption and potential hydrolysis.

How is the impurity indecainide N-oxide monitored during stability?

This oxidative degradation product is quantified using a stability-indicating HPLC method, ensuring it remains below qualification thresholds.