Eribulin

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Cat Number

API441045176

CAS Number

441045-17-6

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Product Detail

CAS Number

441045-17-6

EINECS

813-106-4

Synonyms

Halaven Eribulin mesilate Eribulin (mesylate)

Description

Eribulin mesylate is a methanesulfonate salt obtained by reaction of eribulin with one equivalent of methanesulfonic acid. A fully synthetic macrocyclic ketone analogue of marine sponge natural products. Inhibits growth phase of microtubules via tubulin-based antimitotic mechanism, which leads to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage. It has a role as an antineoplastic agent and a microtubule-destabilising agent. It contains an eribulin(1+).

Molecular Formula

C41H63NO14S

Molecular Weight

826

Appearance

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