Description
(E)-KPT330 is a CRM1-selective inhibitor of nuclear export. It inhibits protein trafficking from the nucleus and induces cell cycle arrest and apoptosis in mesothelioma cells.
Molecular Formula
C17H11F6N7O
Smiles
FC(F)(F)C1CC(CC(C1)C(F)(F)F)-C1NCN(\C=C\C(=O)NNC2CNCCN2)N1
Storage
Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.
Solubility Information
DMSO: 4.43 mg/mL (10 mM)
Relative Density
1.55 (Predicted)