Diclofenac Potassium

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Cat Number

API15307810

CAS Number

15307-81-0

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CAS Number

15307-81-0

EINECS

630-422-6

Storage

2-8℃

Synonyms

potassium 2-(2-(2,6-dichlorophenylamino)phenyl)acetate;Diclofenic potassiuM;Benzeneaceticacid, 2-[(2,6-dichlorophenyl)aMino]-, potassiuM salt

Molecular Formula

C14H10Cl2KNO2

Molecular Weight

334.2

Smiles

C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[K+]

Appearance

White to off-white solid

Melting Point

300-330℃

General Description

Diclofenac Potassium is the potassium salt of diclofenac, a non-steroidal anti-inflammatory drug of the phenylacetic acid class. The potassium salt provides faster dissolution and onset compared to the sodium salt.

Mechanism of Action

Diclofenac inhibits both cyclooxygenase-1 and cyclooxygenase-2 enzymes, reducing prostaglandin and thromboxane synthesis. It demonstrates relatively greater COX-2 selectivity than older NSAIDs, providing anti-inflammatory and analgesic effects.

Application

Used in the treatment of pain and inflammation. Diclofenac Potassium is indicated for rheumatoid arthritis, osteoarthritis, acute musculoskeletal pain, dysmenorrhea, and postoperative pain management.

Halloysite nanotubes were investigated as a novel multifunctional tableting excipient for diclofenac potassium direct compression tablets using the SeDeM diagram expert tool. SeDeM experimentations revealed that approximately 68 percent HNTs in the formulations were sufficient for use as a directly compressible filler, binder, and disintegrant. The compressed tablets exhibited narrow weight variation, good hardness of approximately 9 to 9.5 kg, acceptable friability of less than 0.7 percent, and fast disintegration time of less than 1.5 minutes. Cumulative dissolution at 1 hour in phosphate buffer pH 6.8 exceeded 92 percent, meeting compendial criteria. The dissolution profile best fitted the Peppas-Sahlin model with Fickian diffusion as the only mechanism.

Fig. 2 Preparation and characterization of diclofenac potassium compression tablets. (Ahmed F R.; et al. 2019)

References

Ahmed F R, et al. Clay nanotubes as a novel multifunctional excipient for the development of directly compressible diclofenac potassium tablets in a SeDeM driven QbD environment. European Journal of Pharmaceutical Sciences, 2019, 133: 214-227.

What advantage does the potassium salt form offer?

The potassium salt dissolves more rapidly than the sodium salt, providing faster onset of analgesic action, making it particularly suitable for acute pain management.