Diclofenac Potassium

Halloysite nanotubes were investigated as a novel multifunctional tableting excipient for diclofenac potassium direct compression tablets using the SeDeM diagram expert tool. SeDeM experimentations revealed that approximately 68 percent HNTs in the formulations were sufficient for use as a directly compressible filler, binder, and disintegrant. The compressed tablets exhibited narrow weight variation, good hardness of approximately 9 to 9.5 kg, acceptable friability of less than 0.7 percent, and fast disintegration time of less than 1.5 minutes. Cumulative dissolution at 1 hour in phosphate buffer pH 6.8 exceeded 92 percent, meeting compendial criteria. The dissolution profile best fitted the Peppas-Sahlin model with Fickian diffusion as the only mechanism.

Fig. 2 Preparation and characterization of diclofenac potassium compression tablets. (Ahmed F R.; et al. 2019)