Desmopressin Acetate

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Cat Number

API62288839

CAS Number

62288-83-9

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Product Detail Description Scientific Support Customer Q&A

CAS Number

62288-83-9

EINECS

197-240-2

Synonyms

DESMOPRESSIN MONOACETATE;DESMOPRESSIN ACETATE;DESMOPRESSIN ACETATE SALT;DESMORESSIN ACETATE;Mpr-Tyr-Phe-Gln-Asn-Cys-Pro-D-Arg-Gly-NH2(S-S:1-5);1-(3-Mercaptopropionic acid)-8-D-arginine-vasopressin diacetate;1-Deamino-8-D-arginine-vasopressin diacetate;DDAVP

Molecular Formula

C48H68N14O14S2

Molecular Weight

1129.28

Smiles

CC(=O)O.C1C[C@H](N(C1)C(=O)[C@@H]2CSSCCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N

Appearance

White to off-white solid

Melting Point

170-172℃ (dec.)

Standard

US DMF/CN CDE

General Description

Desmopressin acetate is a synthetic analogue of the natural antidiuretic hormone arginine vasopressin (ADH). Chemically, it is known as 1-(3-mercaptopropionic acid)-8-D-arginine vasopressin monoacetate (salt) . It was developed through structural modifications of the native hormone to enhance specific therapeutic actions while minimizing undesirable effects.

Mechanism of Action

Desmopressin exerts its pharmacological effects primarily through its potent and selective agonist activity at vasopressin V2 receptors. This selectivity is the cornerstone of its dual therapeutic profile.

Application

Desmopressin is the mainstay of replacement therapy for central (cranial) diabetes insipidus. It is used to manage permanent disease and the temporary polyuria and polydipsia following head trauma or pituitary surgery. It is also indicated for patients with hemophilia A who have factor VIII coagulant activity levels greater than 5%.

Desborough MJ, et al. assessed the efficacy of perioperative desmopressin in reducing bleeding and blood transfusion requirements among patients with platelet dysfunction, including those receiving antiplatelet therapy. Pooling data from 10 randomized controlled trials involving 596 cardiac surgery patients, the analysis demonstrated that desmopressin significantly reduced the number of red blood cell units transfused, decreased total blood loss, and lowered the risk of reoperation due to bleeding.

Fig. 1 Forest plots of (A) volume of red cells transfused and (B) risk of allogeneic red cell transfusion. (Desborough MJ, et al., 2017)

References

Desborough MJ, et al. Desmopressin for treatment of platelet dysfunction and reversal of antiplatelet agents: a systematic review and meta-analysis of randomized controlled trials. J Thromb Haemost. 2017, 15(2):263-272.

Does Desmopressin Acetate require special handling during shipment to maintain its peptide integrity?

Yes, to maintain its peptide integrity, Desmopressin Acetate is shipped in temperature-controlled containers (2-8°C) with cold packs and temperature data loggers.

Is Desmopressin Acetate prone to microbial contamination during storage?

While the API itself is not a growth medium, we recommend storing it in a sterile, sealed environment to prevent any potential contamination, as it is often used in sterile formulations.

What specific tests are conducted on Desmopressin Acetate to verify its biological activity?

Beyond chemical purity (HPLC), we conduct a validated bioassay to confirm the specific biological potency of Desmopressin Acetate, ensuring it meets pharmacological standards.

How is the acetate counterion content verified in Desmopressin Acetate?

The acetate content is specifically quantified using Ion Chromatography to ensure correct stoichiometry and salt formation of the peptide.