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Cat Number: API1448347496

Ivosidenib

CAS Number

1448347-49-6

Description

Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. It specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of the oncometabolite 2-hydroxyglutarate (2 hG), which may induce cellular differentiation and inhibit cellular proliferation in IDH1-expressing tumor cells.

Molecular Formula

C28H22ClF3N6O3

Molecular Weight

582.96

Smiles

FC1CNCC(C1)N([C@H](C(=O)NC1CC(F)(F)C1)C1CCCCC1Cl)C(=O)[C@@H]1CCC(=O)N1C1CC(CCN1)C#N

Purity

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

Ethanol: 100 mg/mL (171.54 mM)H2O: < 1 mg/mL (insoluble or slightly soluble)DMSO: 50 mg/mL (85.77 mM)

Relative Density