Decapeptyl

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Cat Number

API124508663

CAS Number

124508-66-3

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Product Detail Description Customer Q&A

CAS Number

124508-66-3

Storage

Under -20°C

Molecular Formula

C87H98N18O19

Molecular Weight

1699.8

Smiles

CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)NC(=O)[C@@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8.C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O

Appearance

White to off-white powder

General Description

Decapeptyl is the acetate salt of triptorelin, a synthetic GnRH (gonadotropin-releasing hormone) decapeptide agonist. It features a D-tryptophan residue at position 6 replacing the glycine of native GnRH, which confers greater receptor binding affinity and resistance to enzymatic degradation compared to the natural hormone.

Mechanism of Action

Decapeptyl initially stimulates pituitary LH and FSH release through GnRH receptor activation, but continuous exposure induces receptor desensitization and downregulation, resulting in profound suppression of gonadal steroidogenesis and a hypogonadic state.

Application

Indicated for the treatment of hormone-dependent cancers including prostate cancer and breast cancer. Decapeptyl (triptorelin) is a synthetic GnRH agonist with D-Trp6 substitution that provides sustained pituitary downregulation and profound suppression of gonadal steroidogenesis through continuous receptor activation.

How does Decapeptyl compare to other GnRH agonists?

Decapeptyl contains a D-Trp6 substitution while goserelin has a D-Ser(tBu)6 substitution, resulting in different receptor binding affinities and pharmacokinetic profiles for cancer therapy.