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Ensartinib hydrochloride

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Cat Number

API2137030987

CAS Number

2137030-98-7

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Product Detail

CAS Number

2137030-98-7

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Description

Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both wild-type ALK and ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of

Molecular Formula

C26H29Cl4FN6O3

Molecular Weight

634.36

Smiles

Cl.Cl.C[C@@H](OC1CC(NNC1N)C(=O)NC1CCC(CC1)C(=O)N1C[C@H](C)N[C@H](C)C1)C1C(Cl)CCC(F)C1Cl

Purity

0.9873

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