Decamethonium Bromide

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Cat Number

API0231585

CAS Number

541-22-0

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Product Detail Description Customer Q&A

CAS Number

541-22-0

EINECS

208-772-2

Storage

Store at room temperature

Synonyms

Decamethonium dibromide; DECAMETHONIUM BROMIDE; Syncurine; Decacuran

Molecular Formula

C16H40Br2N2

Molecular Weight

418.3

Smiles

C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C.[Br-].[Br-]

Appearance

White to almost white powder to crystal

Melting Point

268-270℃

General Description

Decamethonium bromide is a depolarizing neuromuscular blocking agent that was historically used as a muscle relaxant during surgical procedures. It consists of two quaternary ammonium groups linked by a ten-carbon methylene chain. Unlike succinylcholine, decamethonium is not metabolized by plasma cholinesterase and has a longer duration of action, which limited its clinical utility.

Mechanism of Action

Decamethonium acts as an agonist at nicotinic acetylcholine receptors at the motor endplate, causing persistent depolarization of the postsynaptic membrane. This sustained depolarization initially triggers fasciculations followed by flaccid paralysis as sodium channels become inactivated.

Application

Decamethonium was used as an adjunct to general anesthesia to provide skeletal muscle relaxation during endotracheal intubation and surgery. Its use has been largely abandoned in favor of succinylcholine for short procedures and non-depolarizing agents for longer cases due to unpredictable duration, lack of reversibility, and the risk of prolonged apnea.

Does Decamethonium Bromide require protection from light during storage?

Yes, it is photosensitive. Light exposure can cause photodegradation and discoloration. Store in light-resistant containers, preferably amber glass.

What is the recommended storage temperature for Decamethonium Bromide?

Store at controlled room temperature (15-25°C). Avoid excessive heat above 30°C, which can accelerate decomposition of the quaternary ammonium structure.

Is Decamethonium Bromide stable in aqueous solution for diagnostic use?

Aqueous solutions are stable when protected from light and stored at room temperature, but we recommend preparing fresh solutions for extended periods to avoid microbial growth.

How is the impurity decamethylenediamine monitored during stability?

This degradation product (from Hofmann elimination) is quantified using a validated HPLC method with charged aerosol detection, ensuring it remains below acceptable limits.