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Dabrafenib

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Cat Number

API1195765457

CAS Number

1195765-45-7

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Product Detail

CAS Number

1195765-45-7

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Description

Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive. Dabrafenib exhibits antitumor activity for the treatment of B-RafV600E-mutated melanoma.

Molecular Formula

C23H20F3N5O2S2

Molecular Weight

519.56

Smiles

CC(C)(C)C1NC(C(s1)-C1CCNC(N)N1)-C1CCCC(NS(=O)(=O)C2C(F)CCCC2F)C1F

Relative Density

1.443

Purity

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