Clonidine

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Cat Number

API0232246

CAS Number

4205-90-7

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Product Detail Description Customer Q&A

CAS Number

4205-90-7

EINECS

224-119-4

Storage

Store at room temperature

Synonyms

Clonidin; N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine; Chlornidinum; Catapres-TTS; ST-155-BS; Catapresan

Molecular Formula

C9H9Cl2N3

Molecular Weight

230.09

Smiles

C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl

Appearance

White to off-white solid powder

Melting Point

141-142°C

Boiling Point

319.3±52.0°C at 760 mmHg

Relative Density

1.5±0.1

General Description

Clonidine is a synthetic imidazoline derivative with a dichlorophenyl group, acting as a centrally acting alpha-2 adrenergic agonist. Its chemical structure is 2,6-dichloro-N-(2-imidazolidinylidene)aniline. Clonidine is a white to off-white crystalline powder, soluble in water and alcohol. The molecule has a high affinity for alpha-2 adrenergic receptors.

Mechanism of Action

Clonidine acts as a selective agonist at alpha-2 adrenergic receptors in the brainstem (vasomotor center), reducing sympathetic outflow from the central nervous system. This leads to a decrease in peripheral vascular resistance, heart rate, and blood pressure. The drug also has a weak action at imidazoline (I1) receptors, contributing to its antihypertensive effect.

Application

Clonidine is indicated for the treatment of hypertension, particularly in patients who are not controlled on other antihypertensive agents. It is also used for the management of attention-deficit/hyperactivity disorder (ADHD) and for the treatment of opioid withdrawal. The drug is effective in reducing the symptoms of anxiety and panic disorders.

Does Clonidine require protection from light during long-term storage?

Yes, it is photosensitive. UV exposure can cause photodegradation and discoloration of the imidazoline ring. Store in light-resistant containers, preferably amber glass.