Amcinonide

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Cat Number

API51022696

CAS Number

51022-69-6

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Product Detail Description Customer Q&A

CAS Number

51022-69-6

EINECS

256-915-2

Storage

Under -20℃

Synonyms

20-dione,21-(acetyloxy)-16,17-(cyclopentylidenebis(oxy))-9-pregna-4-diene-3

Molecular Formula

C28H35FO7

Molecular Weight

502.6

Smiles

CC(=O)OCC(=O)[C@@]12[C@@H](C[C@@H]3[C@@]1(C[C@@H]([C@]4([C@H]3CCC5=CC(=O)C=C[C@@]54C)F)O)C)OC6(O2)CCCC6

Appearance

White to off-white solid

Melting Point

>216℃

Boiling Point

635.9℃

Relative Density

1.33

pKa

13.09

General Description

Amcinonide is a fluorinated potent topical corticosteroid of the glucocorticoid class, distinguished by enhanced anti-inflammatory potency due to fluorination at the 6-alpha and 9-alpha positions.

Mechanism of Action

Amcinonide binds cytosolic glucocorticoid receptors and the resulting complex translocates to the nucleus, where it induces anti-inflammatory proteins such as lipocortin-1 while suppressing pro-inflammatory cytokines and prostaglandin synthesis.

Application

Used in the treatment of corticosteroid-responsive dermatoses. Amcinonide is indicated for psoriasis, atopic dermatitis, contact dermatitis, and lichen planus requiring high-potency topical therapy.

What is the significance of fluorination in Amcinonide?

Fluorination at the 6-alpha and 9-alpha positions enhances glucocorticoid receptor affinity and metabolic stability, providing potent anti-inflammatory activity at lower concentrations.