Z-HYP-OME

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Cat Number

INT64187480

CAS Number

64187-48-0

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Product Detail Description Customer Q&A

CAS Number

64187-48-0

EINECS

613-498-5

Storage

Store at room temperature

Synonyms

N-Cbz-trans-4-hydroxy-L-proline methyl ester;Z-O-tert-Butyl-L-4-hydroxyproline;(2S,4R)-1-(Benzyloxycarbonyl)-2-(methoxycarbonyl)-4-hydroxypyrrolidine

Molecular Formula

C14H17NO5

Molecular Weight

279.29

Smiles

N1(C(OCC2=CC=CC=C2)=O)C[C@H](O)C[C@H]1C(OC)=O

Appearance

Pale yellow viscous liquid

Boiling Point

422.8℃

Relative Density

1.31

pKa

14.25

General Description

Z-HYP-OME is the N-Cbz protected methyl ester of L-hydroxyproline. The hydroxyl group on the pyrrolidine ring provides an additional site for chemical functionalization.

Mechanism of Action

It serves as a rigid, chiral building block. The Cbz and methyl ester groups provide orthogonal protection, allowing for the selective modification of the 4-hydroxy group via etherification or esterification.

Application

It is essential for the synthesis of collagen-like peptides and as a scaffold in the discovery of ligands targeting HIF-alpha pathways.