Triamcinolone Diacetate

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Cat Number

API67787

CAS Number

67-78-7

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Product Detail Description Customer Q&A

CAS Number

67-78-7

EINECS

200-669-0

Storage

2-8℃

Synonyms

16-(Acetyloxy)-9-fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate

Molecular Formula

C25H31FO8

Molecular Weight

478.5

Smiles

CC(=O)OCC(=O)[C@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)OC(=O)C)O

Appearance

White powder

Melting Point

186-188℃

Boiling Point

608.5℃

Relative Density

1.21

pKa

11.21

General Description

Triamcinolone Diacetate is a synthetic glucocorticoid corticosteroid administered primarily via intra-articular, intralesional, or intramuscular routes as an injectable suspension. The diacetate ester provides a microcrystalline suspension formulation that allows for extended depot-like release from injection sites, prolonging the duration of anti-inflammatory action compared to aqueous solutions of the base steroid.

Mechanism of Action

Triamcinolone Diacetate exerts potent anti-inflammatory and immunosuppressive effects by binding to and activating the glucocorticoid receptor (GR), leading to the regulation of genes involved in inflammatory and immune responses. It inhibits phospholipase A2 through lipocortin-1 induction, suppresses the synthesis of inflammatory prostaglandins and leukotrienes, reduces the synthesis and release of inflammatory cytokines, and suppresses the proliferation and activity of multiple immune cell populations.

Application

Triamcinolone Diacetate is indicated for intra-articular, intrabursal, tendon sheath, and intralesional administration in the treatment of rheumatoid arthritis, osteoarthritis, acute gouty arthritis, and various inflammatory conditions of joints and soft tissues. It is also used for the treatment of allergic and inflammatory conditions of the skin, respiratory tract, and eyes, and for certain adrenal insufficiency states.

What is the recommended storage condition for Triamcinolone Diacetate?

It should be stored at 2-8°C in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Is a Certificate of Analysis (COA) available for Triamcinolone Diacetate?

Yes, a fully verified COA is issued for every batch and can be shared electronically. Additional documentation such as MSDS or impurity profiles may be requested separately.

What is the minimum order quantity (MOQ) for Triamcinolone Diacetate?

Flexible MOQ options are available to support both early-stage research and large-scale manufacturing needs. Our team can tailor order quantities to match your specific requirements.

What is the typical application area for Triamcinolone Diacetate in pharmaceutical manufacturing?

It is commonly used as an active ingredient in topical pharmaceutical formulations. Pharmaceutical-grade material suitable for dermatological product development is available.