Triamcinolone Acetonide

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Cat Number

API76255

CAS Number

76-25-5

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Product Detail Description Scientific Support Advanced Innovations Customer Q&A

CAS Number

76-25-5

EINECS

200-948-7

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Synonyms

Aristogel, Azmacort, Aristoderm

Molecular Formula

C24H31FO6

Molecular Weight

434.5

Smiles

C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)CCC5=CC(=O)C=C[C@@]53C)F)O

Appearance

Crystalline solid

Melting Point

274-278℃

Boiling Point

576.9℃

Relative Density

1.33

General Description

Triamcinolone acetonide is a synthetic fluorinated corticosteroid with potent glucocorticoid and weak mineralocorticoid activity. It is the acetonide salt form of triamcinolone, a derivative of prednisolone, and is characterized by the addition of a fluorine atom and an acetonide group at the C-16, 17 position. These structural modifications significantly enhance its topical and local potency while prolonging its duration of action compared to the parent compound.

Mechanism of Action

Triamcinolone acetonide exerts its profound and sustained pharmacological effects by binding to and activating the cytoplasmic glucocorticoid receptor. The resulting hormone-receptor complex translocates to the nucleus, where it functions as a transcription factor to modulate gene expression.

Application

Triamcinolone acetonide is indicated for a broad spectrum of conditions responsive to corticosteroids, administered via routes that allow for either local or systemic therapy.

In a review of 17 clinical studies by Rahman S et al., suprachoroidal administration of triamcinolone acetonide was found to be effective in reducing macular thickness and improving visual acuity in patients with chorioretinal diseases. The most commonly reported adverse events included eye pain, cataract formation, and elevated intraocular pressure.

Fig. 1 Suprachoroidal administration of a drug and movement of fluid through the suprachoroidal space. (Rahman S, et al., 2024)

References

Rahman S, et al. Suprachoroidal Triamcinolone Acetonide Injection to Treat Macular Edema: A Review. J Vitreoretin Dis. 2024, 8(6):699-708.

Aceves-Franco LA, et al. reviewed the evolution of triamcinolone acetonide (TA) therapeutic use in retinal diseases. Triamcinolone acetonide is the most commonly used synthetic corticosteroid for intraocular applications. Nanoparticle-based delivery systems for TA have been explored as potential minimally invasive alternatives to intravitreal injections for the treatment of posterior segment diseases. Among these novel approaches, topical liposomal formulations have emerged as the most promising strategy.

Fig. 2 Triamcinolone acetonide routes of administration. (Aceves-Franco LA, et al, 2023)

References

Aceves-Franco LA, et al. The Evolution of Triamcinolone Acetonide Therapeutic Use in Retinal Diseases: From Off-Label Intravitreal Injection to Advanced Nano-Drug Delivery Systems. Biomedicines. 2023, 11(7):1901.

What defines the specific surface area of Triamcinolone Acetonide, and why is it important?

Specific surface area is determined by particle size and porosity. It is critical for inhalation products as it directly impacts dissolution rate and lung deposition.

Is Triamcinolone Acetonide stable in common topical cream bases?

We have extensive compatibility data. Generally, it is stable in a wide range of cream and ointment bases, but we recommend conducting stability studies with your specific formulation, as excipients can vary.

How many impurities are typically quantified in your Certificate of Analysis for Triamcinolone Acetonide?

Our standard CoA quantifies not just total impurities, but specifically identifies and reports up to individual known related steroids, providing a comprehensive purity profile.

What is the policy for returning expired Triamcinolone Acetonide?

We generally do not accept returns of expired material. However, we can provide guidance on proper disposal or, for contract customers, discuss consignment stock arrangements to prevent on-site expiration.