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Taletrectinib free base

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Cat Number

API1505514271

CAS Number

1505514-27-1

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Product Detail

CAS Number

1505514-27-1

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Synonyms

AB-106freebase, Taletrectinib free base, IBI-344 free base, DS-6051b free base

Description

Taletrectinib free base (AB-106 free base) is a novel potent, selective and orally active ROS1/NTRK inhibitor.Taletrectinib free base has potent inhibitory effects on recombinant ROS1, NTRK1, NTRK2, and NTRK3, with IC50s of 0.207, 0.622, 2.28 and 0.98 nM, respectively, Taletrectinib free base also inhibited ROS1 G2032R and other Crizotinib-resistant ROS1 mutations.

Molecular Formula

C23H24FN5O

Molecular Weight

405.47

Smiles

N([C@H](C)C1=CC(F)=CC=C1)C2=NN3C(=CN=C3C=C2)C4=CC=C(OC[C@@H](C)N)C=C4

Purity

0.9987

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