Sulfacetamide Sodium

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Cat Number

API127560

CAS Number

127-56-0

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Product Detail Description Scientific Support Customer Q&A

CAS Number

127-56-0

EINECS

204-848-4

Storage

Room temperature

Synonyms

Sodium acetyl((4-aminophenyl)sulfonyl)amide

Molecular Formula

C8H9N2NaO3S

Molecular Weight

236.23

Smiles

CC(=O)[N-]S(=O)(=O)C1=CC=C(C=C1)N.[Na+]

Appearance

White to off-white solid

Melting Point

257℃

General Description

Sulfacetamide Sodium is a sulfonamide antibacterial agent available in topical ophthalmic formulations for the treatment of ocular surface infections. As a sodium salt, it is highly water soluble and has excellent corneal penetration when applied topically. Sulfacetamide competitively inhibits bacterial dihydropteroate synthase (DHPS), blocking the folic acid synthesis pathway in susceptible bacteria.

Mechanism of Action

Sulfacetamide Sodium acts as a competitive inhibitor of bacterial dihydropteroate synthase (DHPS), the enzyme responsible for incorporating p-aminobenzoic acid (PABA) into the dihydropteroate intermediate of the bacterial folic acid synthesis pathway. By blocking folate synthesis, sulfacetamide prevents the production of tetrahydrofolate, which is essential for the synthesis of purines, thymidine, and ultimately bacterial DNA replication. Susceptible organisms include Staphylococcus aureus, Streptococcus species, and certain Gram-negative bacteria.

Application

Sulfacetamide Sodium is indicated for the topical treatment of conjunctivitis, blepharitis, and other superficial ocular infections caused by susceptible strains of Staphylococcus aureus, S. epidermidis, Streptococcus species, Haemophilus influenzae, and other sulfonamide-susceptible organisms.

Sodium sulfacetamide is a sulfonamide antibacterial agent used in dermatology for its anti-inflammatory and antibacterial properties. It inhibits bacterial dihydroperoate synthetase, blocking folic acid synthesis and exerting a bacteriostatic effect against organisms including Propionibacterium acnes. It is typically formulated at 10% concentration, often combined with 5% sulfur for synergistic keratolytic, antibacterial, and antiparasitic effects. Common clinical applications include papulopustular rosacea (twice daily for 8 weeks), acne vulgaris (decreasing inflammatory lesions by 80-83% over 12 weeks), seborrheic dermatitis (improvement in 93% of cases), and perioral dermatitis.

References

Wolf K, Silapunt S. The use of sodium sulfacetamide in dermatology. Cutis, 2015, 96(2): 128-130.

What is the recommended storage condition for Sulfacetamide Sodium?

It should be stored at controlled room temperature in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Is a Certificate of Analysis (COA) available for Sulfacetamide Sodium?

Yes, a fully verified COA is issued for every batch and can be shared electronically. Additional documentation such as MSDS or impurity profiles may be requested separately.

What quantities of Sulfacetamide Sodium are available for order?

We accommodate orders of varying scale, from small research quantities through bulk commercial supply. Contact our sales team to discuss pack sizes and volume pricing.

What organisms is Sulfacetamide Sodium active against?

Activity spectrum information is documented in available scientific literature. Please contact our technical team for detailed microbiological data relevant to your application.