Sodium Phosphate, Dibasic

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Cat Number

API0231530

CAS Number

7558-79-4

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Product Detail Description Customer Q&A

CAS Number

7558-79-4

EINECS

231-448-7

Storage

Store at room temperature

Synonyms

Sodium phosphate dibasic; Disodium hydrogen phosphate; DISODIUM PHOSPHATE; Disodium hydrogenorthophosphate; Acetest

Molecular Formula

Na2HPO4

Molecular Weight

141.96

Smiles

OP(=O)([O-])[O-].[Na+].[Na+]

Appearance

White powder

Melting Point

243-245℃

Relative Density

1.064

General Description

Sodium phosphate, dibasic (disodium hydrogen phosphate) is an inorganic salt used as a source of phosphate and sodium for parenteral nutrition and electrolyte replacement. It is available as a crystalline powder and in sterile solutions for intravenous or oral administration. This agent plays a critical role in maintaining acid-base balance and providing substrate for cellular energy metabolism.

Mechanism of Action

Upon administration, dibasic sodium phosphate dissociates into sodium and monohydrogen phosphate ions, contributing to plasma phosphate and sodium pools. Phosphate is essential for adenosine triphosphate synthesis, 2,3-diphosphoglycerate production in erythrocytes, and as a component of cell membranes and nucleic acids. The monohydrogen form also acts as a buffer, accepting hydrogen ions to maintain systemic pH in metabolic acidosis.

Application

It is indicated for the treatment and prevention of hypophosphatemia in patients with inadequate dietary intake, malabsorption, refeeding syndrome, or renal phosphate wasting. Intravenous administration is reserved for severe hypophosphatemia (serum phosphate less than 1.0 mg/dL) in critically ill patients. Oral formulations are also used as osmotic laxatives for bowel cleansing prior to colonoscopy, though this use requires careful monitoring due to risk of acute phosphate nephropathy.

Does Sodium Phosphate, Dibasic undergo phase transitions at different temperatures?

Yes, the anhydrous form can hydrate to the dihydrate or heptahydrate under high humidity. Store in tightly sealed, moisture-proof containers at controlled room temperature.

What is the recommended storage temperature for Sodium Phosphate, Dibasic?

Store at 15-25°C in a dry environment. Avoid refrigeration, as condensation upon warming can lead to caking and hydrate formation.

Is Sodium Phosphate, Dibasic stable in buffer solutions for biopharmaceutical use?

Yes, it is commonly used in buffer systems. However, solutions should be protected from microbial contamination, and we provide stability data for various pH and temperature conditions.

How is the purity of Sodium Phosphate, Dibasic verified for parenteral applications?

We test for heavy metals, endotoxins, and chloride/phosphate ratio using ion chromatography and USP compendial methods to ensure injectable-grade quality.