SHH-2

HHG1, HHG-1, HLP3, HPE3, MCOPCB5

Sonic Hedgehog (Shh) is expressed in embryonic tissues that are critical for the patterning of the developing central nervous system, somite, and limb. Shh-N is highly conserved, sharing >98% aa identity between mouse, human, rat, canine, porcine, and chicken Shh-N. The Hedgehog (Hh) family of secreted proteins plays an essential role in metazoan development, and defects in the Hh pathway lead to congenital abnormalities such as holoprosencephaly and certain forms of cancer. Shh is the most widely expressed of the many ligands, and much of what is known about vertebrate Hh signaling stems from studies on Shh. Though similar in many ways to the DrosophilaHh pathway, several features of vertebrate Hh signaling make it unique.

Approximately 19.8 kDa.

Sterile Filtered White lyophilized (freeze-dried) powder.

> 95% by SDS-PAGE and HPLC analyses.