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SapitinibAZD-8931

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Cat Number

API848942610

CAS Number

848942-61-0

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Product Detail

CAS Number

848942-61-0

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Description

Sapitinib (AZD-8931) , a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib or Lapatinib against NSCLC cell, 100-fold more specific for the ErbB family over MNK1 and Flt.

Molecular Formula

C23H25ClFN5O3

Molecular Weight

473.93

Smiles

CNC(=O)CN1CCC(CC1)OC1CC2C(NC3CCCC(Cl)C3F)NCNC2CC1OC

Relative Density

1.339

Purity

0.9983

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