An ISO9001 Certified Supplier of Pharmaceutical Ingredients and Specialty Chemicals

Cat Number: API848942610

SapitinibAZD-8931

CAS Number

848942-61-0

Description

Sapitinib (AZD-8931) , a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib or Lapatinib against NSCLC cell, 100-fold more specific for the ErbB family over MNK1 and Flt.

Molecular Formula

C23H25ClFN5O3

Molecular Weight

473.93

Smiles

CNC(=O)CN1CCC(CC1)OC1CC2C(NC3CCCC(Cl)C3F)NCNC2CC1OC

Purity

0.9983

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)H2O: < 1 mg/mL (insoluble or slightly soluble)DMSO: 38 mg/mL (80.2 mM)

Relative Density

1.339

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

INFORMATION

Tel:
E-mail:
Address:
WhatsAPP

Member of

CERTIFICATION