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Cat Number: API1374356452

(S)-crizotinibent-crizotinib

CAS Number

1374356-45-2

Description

(S)-crizotinib (ent-crizotinib) （IC50 of 72 nM）, an effective MTH1 (NUDT1) inhibitor, is the (S)-enantiomer of crizotinib.

Molecular Formula

C21H22Cl2FN5O

Molecular Weight

450.34

Smiles

C[C@H](OC1CC(CNC1N)-C1CNN(C1)C1CCNCC1)C1C(Cl)CCC(F)C1Cl

Purity

0.9989

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

1eq. HCl: 9 mg/mL (20 mM)), Heating is recommended.DMSO: 22.5 mg/mL (50 mM)

Relative Density

1.47 (Predicted)

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