Rapacuronium Bromide

Inquiry

Cat Number

API156137994

CAS Number

156137-99-4

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Product Detail Description Customer Q&A

CAS Number

156137-99-4

Storage

Under -20°C

Synonyms

Rapacuronium;[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-acetyloxy-10,13-dimethyl-2-piperidin-1-yl-16-(1-prop-Chemicalbook2-enylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]propanoate

Molecular Formula

C37H61BrN2O4

Molecular Weight

677.8

Smiles

CCC(=O)O[C@H]1[C@H](C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(C[C@@H]([C@H](C4)OC(=O)C)N5CCCCC5)C)C)[N+]6(CCCCC6)CC=C.[Br-]

Appearance

Yellow solid

Melting Point

184℃

General Description

Rapacuronium Bromide is a non-depolarizing neuromuscular blocking agent of the aminosteroid class. It is structurally related to vecuronium but modified to achieve an ultra-short onset of action comparable to succinylcholine while maintaining the non-depolarizing mechanism.

Mechanism of Action

Rapacuronium Bromide competitively antagonizes acetylcholine at nicotinic receptors on the motor end plate, preventing muscle membrane depolarization. Its rapid onset is attributed to low receptor binding affinity combined with relatively high plasma concentration at the neuromuscular junction.

Application

Used as a rapid-onset neuromuscular blocking agent for tracheal intubation and surgical procedures requiring brief muscle relaxation. Rapacuronium Bromide is an aminosteroid non-depolarizing agent modified to achieve onset times comparable to succinylcholine while maintaining the non-depolarizing mechanism.

How does Rapacuronium Bromide compare to vecuronium in onset?

Rapacuronium Bromide achieves much faster onset than vecuronium due to its lower receptor binding affinity and higher effective concentration at the neuromuscular junction.

What storage conditions are required?

Must be stored under -20℃ in a tightly sealed container, protected from light and moisture.

What purity grade is available?

Supplied as a high-purity grade suitable for R&D and pharmaceutical manufacturing.

Can packaging be customized?

Order quantities and packaging formats can be customized to meet R&D and production requirements.