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Raltitrexed

Raltitrexed

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Cat Number
API112887680
CAS Number
112887-68-0

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CAS Number
112887-68-0
EINECS
652-997-2
Synonyms
Tomudex ZD1694 ZD-1694
Description
Raltitrexed is a quinazoline folate analogue with antineoplastic activity. After transport into cells via the reduced folate carrier, raltitrexed undergoes intracellular polyglutamation and blocks the folate-binding site of thymidylate synthase, thereby inhibiting tetrahydrofolate activity and DNA replication and repair and resulting in cytotoxicity.
Molecular Formula
C21H22N4O6S
Molecular Weight
458.49
Appearance
Yellow Solid
Melting Point
176-180℃ (dec.)
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