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Raltitrexed

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Cat Number

API112887680

CAS Number

112887-68-0

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Product Detail

CAS Number

112887-68-0

EINECS

652-997-2

Synonyms

Tomudex ZD1694 ZD-1694

Description

Raltitrexed is a quinazoline folate analogue with antineoplastic activity. After transport into cells via the reduced folate carrier, raltitrexed undergoes intracellular polyglutamation and blocks the folate-binding site of thymidylate synthase, thereby inhibiting tetrahydrofolate activity and DNA replication and repair and resulting in cytotoxicity.

Molecular Formula

C21H22N4O6S

Molecular Weight

458.49

Appearance

Yellow Solid

Melting Point

176-180℃ (dec.)

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