Pullulan

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Cat Number

PIPE-0112

CAS Number

9057-02-7

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CAS Number

9057-02-7

EINECS

232-945-1

Storage

Store at 2-8℃

Synonyms

Pullulan Standard 6μ000;Pullulan Standard 400μ000; Pullulan Standard 110μ000; Pullulan Standard 320

Molecular Formula

C20H36O16

Molecular Weight

532.49

Appearance

White powder

General Description

Pullulan is an extracellular, linear, film-forming polysaccharide produced by the fermentation of Aureobasidium pullulans. Structurally, pullulan is mostly maltotriose units connected by alpha-1,6 glycosidic linkages. It is this alternating linkage pattern that makes pullulan useful for its superior film-forming abilities, water-holding capacity and viscosity.

Application

Pullulan's most important properties are film forming (producing clear oxygen-barrier films), binder/coating/delivery vehicle. In foods, pullulan is used as an edible packaging film, confection glaze, and stabilizer/thickener. Pharmaceutical uses include tablet coating, drug delivery systems and microcapsule composition. It is useful because of its biocompatible and controlled-release qualities. Cosmetic uses include film former. Pullulan is used in the manufacture of biodegradable plastics and fibers.

Pullulan nanocomposites are hybrid multicomponent biomaterials, formed when pullulan is combined with another polymer like PLGA, Chitosan, Gelatin or Silk fibroin to improve upon drawbacks of each polymer used individually. Pullulan/polymer systems are being used in drug delivery for cancer therapeutics as pullulan can be conjugated to drugs as a pH-sensitive or ligand-targeted (Biotin/ASGPR mediated) shell to improve solubility of hydrophobic anti-cancer drugs like Paclitaxel. This technique allows for higher bioavailability of drugs and less systemic cytotoxicity through "proton-sponge" mediated intracellular release. Pullulan nanocomposites have also found applications in tissue engineering (PVA/Pullulan hydrogels as scaffolds for skin tissue engineering) as well as active food packaging(Pectin or Chitosan-based pullulan composite films). Benefits of pullulan nanocomposites include enhanced mechanical properties, customizable hydrophilicity/hydrophobicity ratios and antimicrobial effects.

Fig. 1 Scanning electron microscopy images of Pullulan/Chitosan nanofiber mats prepared with different mass ratios. (Manivannan M, et al. 2023)

References

Manivannan M, et al. Review on applications of pullulan in bone tissue engineering: Blends and composites with natural and synthetic polymers. Polymers and Polymer Composites. 2023, 31: 09673911231192810.

A hydrogel material with antimicrobial and tissue regeneration properties was synthesized for potential use as a wound healing and burn treatment agent. Pullulan (microbial polysaccharide), chitosan, gelatin and mesenchymal stem cell-conditioned medium were combined into an aqueous solution to form a biocompatible hydrogel. This mixture was created to reach equilibrium between the mechanical strength of the hydrogel while maximizing therapeutic properties. Hydrogel 23 was determined to be the most effective out of the 23 formulas tested, showing a water absorption of 92%, desirable swelling properties, and promising antimicrobial properties against Staphylococcus aureus and Pseudomonas aeruginosa. Hydrogel 23 was found to be non-toxic in vitro and promoted significantly increased fibroblast motility.

Fig. 2 Development of hydrogels based on the microbial polysaccharide pullulan. (Vedyashkina N, et al. 2026)

References

Vedyashkina N, et al. Development of antimicrobial wound healing hydrogels based on the microbial polysaccharide pullulan. Polysaccharides. 2026, 7(1): 7.

Does light exposure affect the quality of Pullulan during long-term storage?

Pullulan should be kept in opaque containers away from direct sunlight.

Who should I contact if my Pullulan packaging arrives damaged?

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Track Pullulan shipments using the link in your dispatch email.

Is after-sales support included with Pullulan orders?

Dedicated rep assists with post-purchase Pullulan queries via email.