Propoxyphene Hydrochloride

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Cat Number

API0232189

CAS Number

1639-60-7

For research use only. We do not supply to patients.

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Product Detail Description Customer Q&A

CAS Number

1639-60-7

EINECS

216-683-5

Synonyms

Algaphan; Deprancol; Propoxyphene HCl; Dextropropoxyphene hydrochloride; Dolene; Kesso-Gesic; Prophene 65; Depronal

Molecular Formula

C22H30ClNO2

Molecular Weight

375.9

Smiles

CCC(=O)O[C@](CC1=CC=CC=C1)(C2=CC=CC=C2)[C@H](C)CN(C)C.Cl

Appearance

White crystalline powder

General Description

Propoxyphene hydrochloride is a synthetic opioid analgesic belonging to the diphenylpropylamine class, structurally related to methadone but with a less potent effect. Its structure consists of a propoxyphene base with a hydrochloride salt, forming a white crystalline powder. The molecule has a chiral center, and the commercial form is the (2S,3R)-isomer, which is the active enantiomer.

Mechanism of Action

Propoxyphene acts as a weak mu-opioid receptor agonist, producing analgesia by binding to opioid receptors in the central nervous system and altering pain perception. It also has mild local anesthetic properties. Its analgesic potency is approximately one-half to one-third that of codeine.

Application

Propoxyphene was indicated for the treatment of mild to moderate pain, often in combination with acetaminophen or aspirin.

Does Propoxyphene Hydrochloride require protection from light during long-term storage?

Yes, it is photosensitive. UV exposure can cause photodegradation and discoloration. Store in light-resistant containers, preferably amber glass.

What are the security requirements for shipping Propoxyphene Hydrochloride as a controlled substance?

Shipments require secure, chain-of-custody protocols with tamper-evident packaging and appropriate DEA documentation.

Is Propoxyphene Hydrochloride hygroscopic, and how is this managed?

It is slightly hygroscopic. Under high humidity (>70% RH), it may absorb moisture and clump. Storage in tightly sealed containers with desiccant is recommended.