Procarbazine Hydrochloride

Inquiry

Cat Number

API366701

CAS Number

366-70-1

If you have any other questions, please contact our experts.

Product Detail Description Scientific Support Customer Q&A

CAS Number

366-70-1

EINECS

206-678-6

Storage

2-8℃

Synonyms

N-(1-methylethyl)-4-[(2-methylhydrazinyl)methyl]-benzamide,hydrochloride

Molecular Formula

C12H20ClN3O

Molecular Weight

257.76

Smiles

CC(C)NC(=O)C1=CC=C(C=C1)CNNC.Cl

Appearance

White to off-white solid

Melting Point

223℃

Relative Density

8.3

General Description

Procarbazine Hydrochloride is an antineoplastic alkylating agent and methylhydrazine derivative used in the combination chemotherapy of Hodgkin's lymphoma and certain brain tumors. It is administered as the hydrochloride salt and acts through multiple mechanisms including DNA alkylation, inhibition of DNA, RNA, and protein synthesis, and induction of chromosomal damage.

Mechanism of Action

Procarbazine Hydrochloride undergoes oxidative activation to reactive intermediates that function as alkylating agents, forming covalent adducts with DNA (particularly at the O-6 position of guanine). This leads to DNA cross-linking, strand breakage, and inhibition of DNA synthesis. Procarbazine also inhibits DNA polymerase, RNA polymerase, and protein synthesis, and may act as a monoamine oxidase (MAO) inhibitor, requiring dietary restrictions.

Application

Procarbazine Hydrochloride is indicated as a component of MOPP (Mustine, Oncovin, Procarbazine, Prednisone) and other combination chemotherapy regimens for the treatment of Hodgkin's lymphoma (stages III and IV) and is used off-label in the treatment of primary brain tumors including glioblastoma multiforme.

Procarbazine is an oral alkylating agent used in Hodgkin lymphoma and brain tumors. It is a prodrug metabolized to active intermediates that inhibit DNA, RNA, and protein synthesis, and crosses the blood-brain barrier. Early MOPP regimen achieved high remission rates but caused infertility and secondary leukemias. Recent dose-intensified BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone) in advanced Hodgkin lymphoma showed 5-year freedom from treatment failure of 87% versus 69% with COPP-ABVD, and overall survival of 91% versus 83%. For anaplastic oligodendroglioma, PCV (procarbazine, lomustine, vincristine) added to radiotherapy prolonged progression-free survival from 13 to 23 months. Despite past safety concerns, procarbazine remains important in modern combination regimens for lymphomas and gliomas, with optimized dosing to reduce late toxicity.

References

Armand J P, et al. Reappraisal of the use of procarbazine in the treatment of lymphomas and brain tumors. Therapeutics and clinical risk management, 2007, 3(2): 213-224.

What is the recommended storage condition for Procarbazine Hydrochloride?

It should be stored at 2-8°C in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Can we obtain batch-specific analytical data for Procarbazine Hydrochloride?

Batch-specific COA documents are standard with every shipment. Additional analytical reports, including HPLC chromatograms or spectral data, may be provided upon request.

What quantities of Procarbazine Hydrochloride are available for order?

We accommodate orders of varying scale, from small research quantities through bulk commercial supply. Contact our sales team to discuss pack sizes and volume pricing.

Does Procarbazine Hydrochloride require any special handling precautions during processing?

As with all potent pharmaceutical intermediates, standard laboratory safety precautions apply. Please refer to the provided SDS for specific handling and disposal guidelines.