PRO-6E

2353493-69-1

PRO-6E is an orally active, Cereblon ligand-based PROTAC that promotes MET degradation, achieving up to 81.9% effectiveness at a concentration of 1 μM in MKN-45 cells. It demonstrates tumor growth inhibition both in vivo and in vitro, alongside inducing cell apoptosis and cell cycle arrest. Notably, its structure comprises a Cereblon ligand (blue), a linker (black), and an ALK/c-Met inhibitor Crizotinib component (pink).

C42H44Cl2FN7O7

848.75

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.