Potassium Lactate

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Cat Number

API996316

CAS Number

996-31-6

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CAS Number

996-31-6

EINECS

213-631-3

Storage

2-8℃

Synonyms

2-hydroxy-propanoic acid monopotassium salt; Monopotassium lactate

Molecular Formula

C3H5KO3

Molecular Weight

128.169

Smiles

CC(C(=O)[O-])O.[K+]

Appearance

Colorless syrupy liquid

Boiling Point

115℃

Relative Density

1.32

General Description

Potassium Lactate is the potassium salt of lactic acid, serving dual functions as a potassium source and as a precursor for bicarbonate generation through hepatic metabolism via the Cori cycle.

Mechanism of Action

Potassium Lactate dissociates into potassium ions that restore intracellular cation balance essential for nerve conduction and cardiac function, while lactate is metabolized to bicarbonate, correcting metabolic acidosis.

Application

Used in the management of electrolyte and acid-base disorders. Potassium Lactate is indicated for hypokalemia with metabolic acidosis, electrolyte depletion, and as a component of balanced resuscitation solutions.

The molecular mechanisms behind lactate's piezo-protective effect on Listeria monocytogenes were investigated using transcriptomic analysis. Exposure of the pathogen to 2.8 percent potassium lactate promoted a shift in its central metabolism, favoring the metabolism of propanediol and ethanolamine together with the synthesis of the B12 cofactor. This metabolic shift suggests the activation of the methyl cycle, which would promote modifications in membrane properties, resulting in an enhanced resistance of the pathogen to high-pressure processing. The study provides insights on the mechanisms developed by L. monocytogenes in response to lactate and/or high-pressure processing and sheds light on the understanding of this piezo-protective effect.

Fig. 1 Predicted carbon flux in L. monocytogenes CTC1034 and EGDe when exposed to lactate. (Serra-Castelló C.; et al. 2021)

References

Serra-Castelló C, et al. Unravelling the molecular mechanisms underlying the protective effect of lactate on the high-pressure resistance of Listeria monocytogenes. Biomolecules, 2021, 11(5): 677.